Saturday, January 28, 2012

US clears Pfizer drug for advanced kidney cancer

(AP) ? Patients with hard-to-treat kidney cancer that has spread to other parts of the body gained a new drug option Friday, after U.S. government regulators approved a twice-a-day pill from Pfizer for the disease.

The Food and Drug Administration approved the company's drug Inlyta as a secondary option for patients with renal cell carcinoma that hasn't responded to previous drug treatments. Renal cell carcinoma is the most common form of kidney cancer, with an estimated 61,000 people in the U.S. newly diagnosed last year, according to the National Cancer Institute. Only about 11 percent of patients with advanced kidney cancer survive five years or more after diagnosis.

Like other recent cancer drugs, Inlyta works by blocking proteins that promote tumor growth and cancer progression.

The market for kidney cancer drugs has grown increasingly crowded in recent years, with six other new drugs approved in the last six years, including Roche's Avastin and GlaxoSmithKline's Votrient. Pfizer's drug is only the second to be designated as a backup, or second-line, treatment after other kidney cancer drugs have been prescribed. Pfizer is also conducting studies of the drug as a first-line option against kidney cancer.

"This is the seventh drug that has been approved for the treatment of metastatic or advanced kidney cell cancer since 2005," said Dr. Richard Pazdur, FDA's cancer drug director, in a statement. "Collectively, this unprecedented level of drug development within this time period has significantly altered the treatment paradigm."

The FDA approved the drug based on a single study in which patients on Inlyta, known chemically as axitinib, experienced two more months without their cancer worsening than patients taking Nexavar, a drug from Bayer and Onyx Pharmaceuticals.

The most common side effects with Inlyta included diarrhea, high blood pressure, fatigue, nausea, weight loss and decreased appetite, among others.

"Even with the advent of targeted therapies, the need remains for additional options for patients with advanced renal cell carcinoma whose disease has progressed following first-line medications," Pfizer Senior Vice President Dr. Mace Rothenberg said in a statement.

Shares of New York-based Pfizer Inc. fell 12 cents to $21.51 in afternoon trading.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2012-01-27-Kidney%20Cancer%20Drug-Pfizer/id-fadd3efcdc33404c8425edb285f83e1c

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Friday, January 27, 2012

Bristol-Myers reports rise in 4th-quarter profit (AP)

NEW YORK ? Bristol-Myers Squibb Co. reported a 76 percent increase in the fourth-quarter profit Thursday, driven in part by sales of a recently-approved diabetes drug and hefty charges a year earlier, though the drugmaker still fell short of Wall Street's expectations.

The company focused attention on rapid sales growth for its three-year-old oral diabetes drug Onglyza, which increased 110 percent to $153 million. But results were dominated by two established products, blood thinner Plavix and the psychiatric drug Abilify.

Net income rose to $852 million, or 50 cents per share, up from $483 million, or 28 cents per share, in the 2010 quarter.

The New York company said fees and discounts under the U.S. health care overhaul reduced earnings per share by 4 cents in the latest quarter. The year-earlier results were weighted down by $324 million in expenses, including charges for streamlining global operations, depreciation and shutdown costs, licensing payments and a tax charge.

Adjusted income rose 12 percent to $906 million, or 53 cents per share, from $807 million, or 47 cents per share, for the same period of 2010. Total sales increased 7 percent to $5.45 billion from $5.11 billion.

Those results were slightly short of analyst expectations as polled by FactSet, which called for 55 cents per share on sales of $5.51 billion.

"Investors weren't expecting much and they didn't get much," said Erik Gordon an analyst and professor at the University of Michigan's Ross School of Business. "A couple of products beat their sales estimates by a hair and a couple missed by a hair."

Bristol-Myers said it expects 2012 full-year earnings per share between $1.90 and $2.00. Analysts are looking for $1.98 per share, on average.

Company shares fell 22 cents to close at $32.48 Friday.

Bristol-Myers and French partner Sanofi SA jointly market Plavix, the world's second-best-selling drug, which posted a 3 percent drop in sales to $1.67 billion. The drug loses U.S. patent protection in May and Bristol has initiated a dozen or more partnerships and deals aimed at developing new revenue-generating products.

Among the most highly anticipated of those drugs is the anti-clotting pill Eliquis, which is approved in the European Union for preventing clots in patients getting hip or knee replacement surgery. Bristol and its partner on the drug, Pfizer Inc., are seeking U.S. approval for the drug for stroke prevention, which would allow them to market it for millions more patients. The Food and Drug Administration has given Eliquis a priority review, with a March 28 target date for a ruling.

Also scheduled to lose patent protection in the coming year is the blood pressure drug Avapro. Sales of that drug and its foreign counterpart Avalide fell 23 percent, to $195 million. That's because they have generic competition in Canada, a rival's similar drug has generic competition in many countries, and one of the three dosage forms isn't available due to a recall.

Sales of the company's second biggest product, schizophrenia and bipolar drug Abilify, rose 4 percent to $737 million.

For full-year 2011 the company earned $3.71 billion, or $2.16 per share, on sales of $21.24 billion. Excluding one-time items income was $2.28 per share.

Source: http://us.rd.yahoo.com/dailynews/rss/earnings/*http%3A//news.yahoo.com/s/ap/20120126/ap_on_bi_ge/us_earns_bristol_myers

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5 things we learned from Thursday's debate (CNN)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/192123467?client_source=feed&format=rss

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Thursday, January 26, 2012

Sajak: Vanna and I drank between 'Wheel' tapings (AP)

NEW YORK ? The "Wheel of Fortune" wasn't the only thing spinning for Pat Sajak and Vanna White back in the day.

Sajak said in an interview on ESPN2 this week that the long-time game show team would occasionally walk over to a restaurant for "two or three or six" margaritas during a break in taping early "Wheel of Fortune" shows in California. Sajak has hosted the show since 1981; White joined him a year later.

Sajak recalled the margarita stops after answering "yes" to a question about whether he had ever hosted the show "a little bit drunk."

Although he joked that he had "trouble recognizing the alphabet" for shows taped after the drinks, no one ever said anything to them.

Now that he's older, Sajak said he couldn't do that anymore.

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20120126/ap_on_en_tv/us_people_sajak

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Politics of defense cuts: emphasize the positive (AP)

WASHINGTON ? The Pentagon is preparing to tighten its belt, but with an election-year battle looming in Congress and on the presidential campaign trail, Defense Secretary Leon Panetta wants to stress the positive: Parts of the budget devoted to reshaping the military to fit a new global strategy will actually get fatter, he says.

But that's unlikely to mollify Republicans who say President Barack Obama's plan will leave the Pentagon stretched too thin to handle potential security threats in the Middle East, Asia and beyond.

Panetta is expected to outline the main areas of proposed spending cuts and increases at a Pentagon news conference Thursday, more than two weeks before the Obama administration submits its 2013 budget proposal to Congress. He will be joined by Army Gen. Martin Dempsey, chairman of the Joint Chiefs of Staff, for a presentation designed to highlight the military leadership's embrace of defense cuts.

Panetta and Dempsey are expected to cast the plan as one that reflects President Barack Obama's strategy for reorienting the military as it recovers from a decade of war in Iraq and Afghanistan.

Prominent in the Obama plan is a renewed focus on Asia, where China's rapid military modernization has raised worry in Washington and rattled U.S. allies. That, along with continued security threats in the Middle East ? especially Iran ? is why Panetta wants to invest more in certain air and naval assets. He also is putting a focus on cybersecurity and commando forces like those who killed Osama bin Laden last May and who swooped into Somalia on Tuesday to rescue two hostages, including an American.

The Pentagon has embraced a proposal by special operations chief Adm. Bill McRaven to send more manpower and equipment to worldwide "Theater Special Operations Commands" to strike back wherever threats arise, according to a senior defense official who spoke to The Associated Press, and other current and former U.S. officials briefed on the program. The officials spoke on condition of anonymity because the details of the proposal are still being worked out, including how fast the changes could be made.

The stepped-up network would put top special operations personnel closer to the problems they face, better able to launch unilateral raids like this week's Somalia mission. McRaven also wants the newly invigorated commands to build new relationships with foreign armies to help them lead their own operations, the senior defense official said.

To save money, Panetta would reduce the size of Army and Marine Corps ground forces and shrink the U.S. presence in Europe, while maintaining a commitment to building missile defenses in Europe.

He also is expected to delay production of perhaps 100 or more of the F-35 Lightning II stealth attack planes that the Air Force, Navy and Marine Corps are counting on to replace a portion of their aging aircraft fleets. The F-35 is the Pentagon's most expensive weapons program. Nonetheless, it is among those that Panetta has publicly identified as central to a strategy for maintaining American air dominance.

According to defense officials, substantial budget savings will come from slowing ? but not eliminating ? programs. In the case of the F-35, Loren Thompson, defense analyst at the Lexington Institute, said there are no plans to cut the total number of fighters purchased ? which is about 2,400. Instead, the intention is to reduce the number bought each year over the next five years.

The construction of some Navy ships also may be stretched out over a longer period.

Panetta also has made clear the administration will resist any effort to shrink the Navy's fleet of aircraft carriers. He said last weekend while on board the fleet's oldest carrier, the USS Enterprise, that keeping 11 of the warships is a "long-term commitment" that Obama believes is important to keeping the peace.

"Our view is that the carriers, because of their presence, because of the power they represent, are a very important part of our ability to maintain power projection both in the Pacific and in the Middle East," he said.

Obama has said he hopes to further reduce the size of the U.S. nuclear arsenal, but Panetta is expected to make clear that the basic structure ? a "triad" of land, sea and air nuclear forces ? will be maintained. The Pentagon may find some savings by stretching out planned modernization programs.

The defense budget is being reshaped in the midst of a presidential contest in which Obama seeks to portray himself as a forward-looking commander in chief focusing on new security threats. Republicans want to cast him as weak on defense.

Obama has highlighted his national security successes ? the killing of Osama bin Laden, the death of senior al-Qaida leaders and the demise of Libya's Moammar Gadhafi ? to counter Republican criticism. He also has emphasized the completion of the U.S. troop withdrawal from Iraq and the start of a drawdown in Afghanistan as turning points that offer new opportunities to scale back defense spending.

But several congressional Republicans see a political opening in challenging the reductions in projected military spending that the GOP and Obama agreed to last summer as part of a deal to raise the nation's borrowing authority. They've echoed Obama's potential presidential rivals Mitt Romney, Newt Gingrich and Rick Santorum, who plead for fiscal austerity but contend that sizable cuts would gut the military.

The defense budget this year is nearly $671 billion, including a base budget of $553 billion and $118 billion in war costs. Panetta is expected to announce on Wednesday that the administration's request for 2013 will drop to about $525 billion for the base budget. That is still far higher than the $480 billion base budget for the Pentagon in 2008, President George W. Bush's final year in office.

The administration's projected defense cuts would total nearly $490 billion over 10 years. If Congress fails to agree on other reductions in federal spending this year, the defense hit could double under automatic cuts that would take effect in January 2013.

Several Republicans argue that even the initial cuts totaling nearly $490 billion would "hollow" the military and costs tens of thousands of jobs nationwide, adding to an 8.5 percent unemployment rate that they already blame on the president's economic policies.

"While Secretary Panetta has conceded that our nation is now accepting more risk as a result of the budgetary vise squeezing the Pentagon, it remains unclear exactly what risks our nation is assuming," Rep. Randy Forbes, R-Va., a House Armed Services Committee member, said this week.

___

Associated Press writers Kimberly Dozier and Lolita C. Baldor contributed to this report.

___

Robert Burns can be reached on Twitter at http://www.twitter.com/robertburnsAP

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/ap/20120126/ap_on_go_ca_st_pe/us_defense_budget

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Wednesday, January 25, 2012

House will take up Giffords border bill (Politico)

In her last official act before resigning from the House, Rep. Gabrielle Giffords will get to vote on her own bill cracking down on cross-border drug smuggling.

House Majority Leader Eric Cantor (R-Va.) has scheduled the ?ultralights? measure for a vote under suspension of the rules on Wednesday.

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Giffords, who has spent the past year recovering from a failed assassin?s bullet, announced on Sunday that she will resign from the House this week in order to concentrate on her rehabilitation. She is expected to attend the president?s State of the Union address Tuesday night and to be on the floor for Wednesday?s vote before submitting her resignation.

The bill, which would apply anti-smuggling laws to ultralight aircraft now used by traffickers to move illegal drugs across the U.S.-Mexican border, was introduced last night by Rep. Jeff Flake (R-Ariz.) with Giffords as the primary cosponsor. The House passed the legislation in the last Congress, but it died in the Senate.

The Senate then passed it last year, but that measure was blocked in the House with a ?blue slip? ? which means it was objected to on the grounds that the Constitution prohibits a bill containing tax provisions from originating in the Senate.

So, Flake, who has been working with Giffords? aides to get it into law this year, introduced a fresh version with his colleague. Mark Kelly, Giffords?s husband, spoke with Cantor recently about trying to get the bill to the floor for a vote.

Sen. Tom Udall (D-N.M.) is working to get quick approval of the new House bill in the Senate so that it can be sent to the White House.

Correction: Tom Udall is from New Mexico. The original version of this story listed the incorrect state.

Source: http://us.rd.yahoo.com/dailynews/rss/politics/*http%3A//us.rd.yahoo.com/dailynews/external/politico_rss/rss_politico_mostpop/http___www_politico_com_news_stories0112_71890_html/44288823/SIG=11mgheop0/*http%3A//www.politico.com/news/stories/0112/71890.html

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Anonymous Says They'll Attack Facebook Next - Business Insider

In the wake of the federal takedown of Megaupload, hacker collective Anonymous has been on a retaliatory spree.

Yesterday, they managed to divert all traffic away from CBS.com, following their takedowns of government sites and Universal Music Group last week.

And according to a video posted this morning on a seemingly Anonymous-affiliated YouTube account, Facebook is their next target. The video encourages people to download a linked program that they can use to attack Facebook.

This isn't the first time they've threatened Facebook, but if this video's authentic, it means the threat could be acted upon soon. Other sites they've mentioned as targets in the past include the United Nations, Xbox Live, U.S. Bank, Twitter, and YouTube.

UPDATE 4:45 p.m. ? The Anonymous-affiliated Twitter account @anonops has tweeted that they, at least, will not attack Facebook. (via PCMag)

Here's the video:

Source: http://www.businessinsider.com/anonymous-says-its-going-to-attack-facebook-next-2012-1

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