Monday, June 3, 2013

ASUS Zenbook Infinity official with a Gorilla Glass 3 lid, touchscreen and backlit keyboard (eyes-on video)

ASUS Zenbook Infinity with Gorilla Glass 3 lid unveiled

Just as promised, ASUS has unveiled its Zenbook Infinity at Computex 2013 in Taipei. Being the first laptop -- let alone an Ultrabook -- to boast a Gorilla Glass 3 lid, it's able to take advantage of three times the scratch resistance than the material's predecessor. This has allowed ASUS to achieve a maximum thickness of just 15.5mm, or about 14 percent thinner than the previous line of Zenbooks. But would the glass survive a drop? According to the product manager, the laptop's passed various drop tests, but only time will tell if it's as good as he promised.

Despite the slimmer body, the Zenbook Infinity surprises us with a built-in touchscreen as well as a backlit keyboard. There's also a USB 3.0 port on each side, along with an SD card slot, micro-HDMI port and a Mini DisplayPort. No word on the other specs or prices just yet as this laptop won't be out until Q4, so stay tuned for future announcements. Check our our eyes-on video after the break.

Filed under: ,

Comments

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/oiKR0QIKJaM/

belize resorts nikki minaj grammy performance shel silverstein niki minaj grammy performance

A SlingSword Is A Sword/Slingshot Hybrid For Fighting Zombies

Joerg Sprave is expanding his horizons and moving The Slingshot Channel into a new era. He had blacksmith James Helm make him a small sword and this demo is a relaxing break for all of us. Just some good old fashioned coconut decapitation to test the blade. Refreshing! Oh, and the hilt of the sword also has a built-in slingshot. Baby steps.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/9vxKoKLR1CA/a-slingsword-is-a-sword-slingshot-hybrid-for-fighting-z-510941242

the happening black panthers mauritania obama open mic

Angelina Jolie makes first public appearance after mastectomy

By Edward Baran

LONDON (Reuters) - Angelina Jolie made her first public appearance since announcing her double mastectomy on Sunday, joining fiance Brad Pitt on the red carpet in London where she welcomed the debate on women's health that the surgery had sparked.

The Oscar-winning actress has stayed out of the spotlight since announcing her operation in a New York Times column last month, saying the decision was made after finding she carried a gene giving her an 87 percent chance of getting breast cancer.

The 37-year-old mother of six, praised for her courage in publicly announcing her surgery, is now reported to be planning another operation to remove her ovaries as the BRCA1 gene also gives her a 50 percent chance of ovarian cancer.

On the red carpet for the world premiere of Pitt's latest movie, zombie blockbuster "World War Z", Jolie praised her partner as being "a wonderful man and a wonderful father.

"I'm very, very grateful for all the support ... and I have been very happy just to see the discussion of women's health expanded and that means the world to me," she told reporters.

"After losing my mom to these issues, I am very grateful for it," added the American actress, wearing a long black, backless Yves Saint Laurent dress.

Jolie's mother, actress Marcheline Bertrand, died from ovarian cancer in 2007 at the age of 56 and her aunt, 61-year-old Debbie Martin, died last week as a result of breast cancer.

Jolie missed her aunt's funeral to accompany Pitt to London for the premiere of "World War Z", an adaptation of Max Brooks' 2006 apocalyptic novel.

Pitt's production company Plan B Entertainment bought the screen rights to the novel about six years ago and it is one of the big box office releases this summer, but it is under pressure to perform before even opening.

It was due to be released late last year but suffered setbacks amid reports that the budget had ballooned above $200 million and Pitt clashed with director Marc Forster.

In "World War Z", Pitt plays United Nations representative Gerry Lane who is enlisted to help stop a zombie pandemic that is toppling armies and governments and threatening to destroy mankind.

Pitt said he was proud of the film and also of Jolie for her decision to have a mastectomy for the sake of their family and to share that experience.

"When she's faced with a problem - and we have known this was coming for some time - she takes it by the horns," Pitt, 49, also dressed in black, told reporters. "I'm super proud of her. She's a bad ass."

Asked how important it was to have her on the red carpet with him, Pitt said: "It's just more fun to do these things with each other. More fun when she's around and same for her."

"World War Z" marks Pitt's first foray as the star and producer of his own potential franchise.

Pitt said his own children's reaction to the book sparked the project which ultimately was about survival and family.

"The boys love a zombie," he said.

(Writing by Belinda Goldsmith)

Source: http://news.yahoo.com/angelina-jolie-makes-first-public-appearance-mastectomy-212842499.html

Election Election results 2012 exit polls Presidential Polls

No increased risk of infection for long-term sex partners of people with HPV-related oral cancers, study suggests

June 1, 2013 ? Spouses and long-term partners of patients with mouth and throat cancers related to infection with the human papilloma virus (HPV) appear to have no increased prevalence of oral HPV infections, according to results of a multicenter, pilot study led by Johns Hopkins investigators. The study?s results suggest that long-term couples need not change their sexual practices, say the scientists.

?While we can?t guarantee that the partners of patients will not develop oral HPV infections or cancers, we can reassure them that our study found they had no increased prevalence of oral infections, which suggests their risk of HPV-related oral cancer remains low,? says Gypsyamber D?Souza, Ph.D., M.P.H., associate professor of epidemiology at the Johns Hopkins University Bloomberg School of Public Health. She is expected to present the results of her study June 1 at the 2013 American Society of Clinical Oncology Annual Meeting.

HPV-related oral cancers are rising in prevalence among white men in the United States, and fear of transmitting the virus can lead to anxiety, divorce, and curtailing of sex and intimacy among couples, says D?Souza. Persistent oral HPV infections are a risk for developing oropharyngeal cancers, located at the base of the tongue, tonsils, pharynx and soft palate.

At the Johns Hopkins Hospital and three other hospitals, researchers conducted surveys and took oral rinse samples from 166 male and female patients with HPV-related oropharyngeal cancers and 94 spouses and partners. The scientists also studied patients? tumor samples and performed visual oral examinations of spouses/partners. Of the 94 spouses/partners, six were male.

More than half of patients had at least one type of HPV DNA detectable in their oral rinses, including HPV16, the viral type most commonly associated with oral and other cancers. After a year, only seven patients (six percent) still had oral HPV16 DNA detectable.

Of the 94 spouses/partners, six had oral HPV infections (6.5 percent). Among the six, none of the men and two of four females (2.3 percent) had HPV16 infections at very low levels. These infections were not detectable one year later. No oral cancers were detected among 60 spouses/partners who underwent a visual oral exam.

One spouse and one patient reported a history of cervical cancer. Two spouses reported a history of cervical pre-cancer, and three patients said they had previous spouses with cervical cancers, but these were self-reported, unconfirmed cases.

?The oral HPV prevalence among partners who participated in this study are comparable to rates observed among the general population,? says D?Souza. ?We suspect that long-term spouses and partners have been exposed to HPV, like most of us, and appear to have cleared the virus.?

D?Souza and her colleagues recommend that long-term couples need not change their sexual practices. ?Certainly, with new sexual partners, caution is always advised.?

More research is needed to determine the timeline of progression for HPV-related oral cancers and how HPV is transmitted and suppressed by the immune system, adds D?Souza.

Funding for the study was provided by the Johns Hopkins Innovation Fund and the Richard Gelb Cancer Prevention Award.

Scientists contributing to the research include Neil Gross from the Oregon Health & Science University; Maura Gillison from the Ohio State University; Sara Pai from Johns Hopkins; Robert Haddad from the Dana Farber Cancer Center; and Marshall Posner from Mount Sinai Medical Center.

ASCO Abstract #6031: Oral HPV infection in HPV-positive oropharyngeal cancer cases and their spouses.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/ViWwN0OExCc/130601133643.htm

kourtney kardashian kourtney kardashian DNS Changer ernest borgnine

New technology makes breast cancer surgery more precise

June 1, 2013 ? Any breast cancer surgeon who regularly performs lumpectomies confronts the question "Did I get it all?" Thirty to 60 percent of the time in the U.S., the answer is "no," requiring the patient to undergo a second surgery to remove the remaining tumor.

Surgeons at UC Irvine Medical Center are the first in the country to use a device that reduces by half the need to reoperate and cut out breast cancer cells missed during an initial lumpectomy. The MarginProbe System lets the surgeon immediately assess whether cancer cells remain on the margins of excised tissue. Currently, patients have to wait days for a pathologist to determine this.

"All of my patients know someone who has had to go back into surgery because their doctor didn't get the entire tumor out," said UC Irvine Health surgical oncologist Dr. Alice Police. "The ability to check tissue in the operating room is a game changer in surgery for early-stage breast cancer."

The goal in a lumpectomy is to completely remove the cancer while preserving as much normal breast tissue as possible. If a pathologist finds cancer cells on the edges of the tissue taken out, surgeons must assume the lumpectomy didn't get the entire tumor.

The Food & Drug Administration approved MarginProbe in December 2012, and UC Irvine Medical Center is the first hospital in the U.S. to employ the system, according to manufacturer Dune Medical Devices.

Police, assistant professor of surgery at UC Irvine and medical director of Pacific Breast Care in Costa Mesa, and Dr. Karen Lane, associate professor of surgery and clinical director of the UC Irvine Health Breast Health Center in Orange, began operating with MarginProbe in early March.

They had participated in an FDA trial that included more than 660 women across the U.S. In the prospective, multicenter, randomized, double-arm study, surgeons applied the device to breast tissue removed during in-progress initial lumpectomies and, if indicated, shaved additional tissue on the spot. This was found to reduce by 56 percent the need for repeat surgeries.

"It will save you a lot of anxiety," said Jane Madigan, a Costa Mesa resident who underwent the procedure with Police as part of the MarginProbe trial. "You will come out of that surgery knowing you are cancer-free."

The system comprises a sterile handheld probe and a portable console. When the probe tip touches an excised lumpectomy specimen, radio-frequency signals are transmitted into the tissue and reflected back to the console, where they are analyzed using a specialized algorithm to determine tissue status.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/L-WrUMEAbOU/130601133929.htm

pope shenouda bolton muamba crystal cathedral sxsw

LG Optimus F7 for US Cellular leaks through company documents

LG Optimus F7 for US Cellular leaks out

US Cellular isn't just looking to spice up its device roster with the ATIV Odyssey. We've obtained documents that point to LG's upper mid-range Android smartphone, the Optimus F7, also reaching the carrier in the near future. Outside of the unintrusive branding on the back, it's a very straightforward port: the F7 should still carry its 4.7-inch qHD screen, LTE data, a dual-core 1.5GHz processor, an 8MP rear camera and a 1.3MP front camera. The materials we've seen make no mention of launch details, although we're not expecting either a long wait or a high price.

[Thanks, anonymous tipster]

Filed under: , ,

Comments

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/PmMiQraQfEg/

2012 australia Brothers Grimm Tate Stevens

Sunday, June 2, 2013

The Weekly Roundup for 05.27.2013

The Weekly Roundup for 12032012

You might say the week is never really done in consumer technology news. Your workweek, however, hopefully draws to a close at some point. This is the Weekly Roundup on Engadget, a quick peek back at the top headlines for the past seven days -- all handpicked by the editors here at the site. Click on through the break, and enjoy.

Comments

Source: http://www.engadget.com/2013/06/02/the-weekly-roundup-for-05-27-2013/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

nfl free agents 2012 encyclopedia brittanica nfl free agency jonbenet ramsey

House panel: Report finds $50M for IRS conferences

(AP) ? A government watchdog has found that the Internal Revenue Service spent about $50 million to hold at least 220 conferences for employees between 2010 and 2012, according to a House committee.

That total included $4 million for an August 2010 conference in Anaheim, Calif., for which the agency did not negotiate lower room rates, even though that is standard government practice, according to a statement by the House Oversight and Government Reform Committee.

Instead, some of the 2,600 attendees received benefits, including staying in expensive presidential suites. In addition, 15 outside speakers were paid a total of $135,000 in fees, with one paid $17,000 to talk about "leadership through art," the House committee said.

The report by Treasury Department's inspector general, set to be released Tuesday, comes as the IRS already is facing bipartisan criticism after agency officials disclosed they had targeted tea party and other conservative groups seeking tax-exempt status to extra scrutiny.

Agency officials and the Obama administration have said that treatment was inappropriate. But the political tempest is showing no signs of ebbing and has put the White House on the defensive. Three congressional committees are investigating and a Justice Department criminal investigation is underway, and President Barack Obama has replaced the IRS's acting commissioner while two other top officials have stepped aside.

On Friday, the new acting commissioner, Danny Werfel, released a statement on the forthcoming report criticizing the Anaheim meeting.

"This conference is an unfortunate vestige from a prior era," Werfel said. "While there were legitimate reasons for holding the meeting, many of the expenses associated with it were inappropriate and should not have occurred."

Werfel, a former official at the White House Office of Management and Budget, said reducing excessive personal travel has been "a personal priority for me" and that "taxpayers should take comfort that a conference like this would not take place today."

The report will be the subject of a hearing Thursday by the House Oversight and Government Reform Committee.

Werfel is scheduled to make his first congressional appearance as acting commissioner Monday when he appears Monday before a subcommittee of the House Appropriations Committee.

According to congressional aides briefed by the inspector general's office, the IRS also did not formally seek competitive bids for the city where the agency's 2010 conference was held, for the event planner who assisted the agency, or for the speakers.

The aides, who spoke on condition of anonymity to describe a confidential congressional briefing, said other benefits given to some attendees at the Anaheim IRS conference included vouchers for free drinks and some tickets to attend Angels baseball games.

"So they end up with free drinks, they ended up with tickets to games, basically kickbacks," the committee chairman, Rep. Darrell Issa, R-Calif., said Sunday on CNN's "State of the Union."

Two videos produced by the IRS were shown at the Anaheim conference. In one, agency employees did a parody of "Star Trek" while dressed like the TV show's characters; the second shows more than a dozen IRS workers dancing on a stage. The two cost the agency more than $50,000 to make, aides said.

The lecturer who spoke about art through leadership produced six paintings while speaking with subjects that included Abraham Lincoln, Michael Jordan, the rock singer Bono and the Statue of Liberty, the aides said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-06-02-IRS%20Investigation/id-74284594fd25417aa022290798d4ccef

Medal of Honor Warfighter Richard Mourdock d t

Frightened Okla. residents opt to flee tornadoes

Josh Stapleton, left, and Dan Garrett help to salvage furniture from their friends Fred and Joann Horn's home that was destroyed by the tornado Saturday, June 1, 2013 in El Reno Okla. (AP Photo/Nick Oxford)

Josh Stapleton, left, and Dan Garrett help to salvage furniture from their friends Fred and Joann Horn's home that was destroyed by the tornado Saturday, June 1, 2013 in El Reno Okla. (AP Photo/Nick Oxford)

Joshua Lamb stands near what was once he and his family's home that was left in ruins by a tornado, Saturday June 1, 2013 in El Reno Okla. (AP Photo/Nick Oxford)

Josh Hill, a volunteer with Grace Chapel in Englewood, Colo., helps to clear downed branches from Angela and Wade Burleson's yard in El Reno Okla. on Saturday June 1, 2013 after their home was destroyed by one of the tornados that swept through Central Okla. on Friday. (AP Photo/Nick Oxford)

A vehicle lies upside-down at the Canadian Valley Technology Center in El Reno Okla. on Saturday June 1, 2013 after tornadoes swept through central Oklahoma on Friday. (AP Photo/Nick Oxford)

Overturned trucks block a frontage road off I-40 just east of 81 in El Reno, Okla., after a tornado moved through the area on Friday, May 31, 2013. (AP Photo/The Oklahoman, Jim Beckel) LOCAL STATIONS OUT (KFOR, KOCO, KWTV, KOKH, KAUT OUT); LOCAL WEBSITES OUT; LOCAL PRINT OUT (EDMOND SUN OUT, OKLAHOMA GAZETTE OUT) TABLOIDS OUT

(AP) ? It's a warning as familiar as a daily prayer for Tornado Alley residents: When a twister approaches, take shelter in a basement or low-level interior room or closet, away from windows and exterior walls.

But with the powerful devastation from the May 20 twister that killed 24 and pummeled the Oklahoma City suburb of Moore still etched in their minds, many Oklahomans instead opted to flee Friday night when a violent tornado developed and headed toward the state's capital city.

It was a dangerous decision to make.

Interstates and roadways already packed with rush-hour traffic quickly became parking lots as people tried to escape the oncoming storm. Motorists were trapped in their vehicles ? a place emergency officials say is one of the worst to be in a tornado.

"It was chaos. People were going southbound in the northbound lanes. Everybody was running for their lives," said Terri Black, 51, a teacher's assistant in Moore.

After seeing last month's tornado also turn homes into piles of splintered rubble, Black said she decided to try and outrun the tornado when she learned her southwest Oklahoma City home was in harm's way. She quickly regretted it.

When she realized she was a sitting duck in bumper-to-bumper traffic, Black turned around and found herself directly in the path of the most violent part of the storm.

"My car was actually lifted off the road and then set back down," Black said. "The trees were leaning literally to the ground. The rain was coming down horizontally in front of my car. Big blue trash cans were being tossed around like a piece of paper in the wind.

"I'll never do it again."

Oklahoma Highway Patrol Trooper Betsy Randolph said the roadways were quickly congested with the convergence of rush-hour traffic and fleeing residents.

"They had no place to go, and that's always a bad thing. They were essentially targets just waiting for a tornado to touch down," Randolph said. "I'm not sure why people do that sort of stuff, but it is very dangerous. It not only puts them in harm's way, but it adds to the congestion. It really is a bad idea for folks to do."

At least nine people were killed in Friday's storms, including a mother and her baby sucked out of their car as a deadly EF3 twister tore its way along a packed Interstate 40 near the town of El Reno, about 30 miles from Oklahoma City.

A 4-year-old boy died after being swept into the Oklahoma River on the south side of Oklahoma City, said Oklahoma City police Lt. Jay Barnett. The boy and other family members had sought shelter in a drainage ditch.

More than 100 people were injured, most of those from punctures and lacerations from swirling debris, emergency officials reported.

A total of five tornadoes struck the Oklahoma City metro area, the National Weather Service said.

Oklahoma wasn't the only state to see violent weather on Friday night. In Missouri, areas west of St. Louis received significant damage from an EF3 tornado that packed estimated winds of 150 mph. In St. Charles County, at least 71 homes were heavily damaged and 100 had slight to moderate damage, county spokeswoman Colene McEntee said.

Tens of thousands were without power, and only eight minor injuries were reported. Gov. Jay Nixon declared a state of emergency.

Northeast of St. Louis and across the Mississippi, the city of Roxana was hit by an EF3 tornado as well, but National Weather Service meteorologist Jayson Gosselin said it wasn't clear whether the damage in both states came from the same EF3 twister or separate ones.

Back in Oklahoma, Amy Williamson, who lives just off I-40 in the western Oklahoma City suburb of Yukon, said when she learned the tornado was moving toward her home, she piled her two young children, baby sitter and two cats into her SUV.

"We felt like getting out of the way was the best idea," Williamson said. "It was 15 minutes away from my house, and they were saying it was coming right down I-40, so we got in the car and decided to head south."

Williamson said she knows emergency officials recommend taking shelter inside a structure, but fresh in her mind was the devastation of the Moore tornado. Seeing homes stripped to their foundation made her think that fleeing was the best idea, she said.

"I'm a seasoned tornado watcher ... but I just could not see staying and waiting for it to hit," she said. She ended up riding out the storm in a hospital parking garage.

On Saturday, muddy floodwaters stood several feet deep in the countryside surrounding the metro area. Torrential downpours followed for hours after the twisters moved east ? up to 7 inches of rain in some parts ? and the city's airport had water damage. Some flights resumed Saturday.

The Oklahoma County Sheriff's Office said the body of a man who went missing from his vehicle early Saturday near Harrah, east of Oklahoma City, was found later in a creek by deputies. Roadways around the area were crumbling because of water, especially near an intersection in northeastern Oklahoma City and in Canadian County south of I-40, between Mustang and Yukon.

When the storm passed between El Reno and Yukon, it barreled down I-40 for more than two miles, ripping billboards down to twisted metal frames. Debris was tangled in the median's crossover barriers, including huge pieces of sheet metal, tree limbs and a giant oil drum. The warped remains of a horse trailer lay atop a barbed-wire fence less than 50 yards from the highway.

The Oklahoma Corporation Commission reported more than 91,800 homes and businesses across the state remained without power Saturday.

___

Sean Murphy can be reached at www.twitter.com/apseanmurphy.

___

Associated Press writers Ken Miller in Oklahoma City and Jim Suhr in St. Louis contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-06-01-Severe%20Weather/id-98784655b0c3403c8edd50fe8f86d5a5

shell houston open mega millions winners anthony davis toure

Dutch authorities to cull poultry after avian influenza outbreak

By Gary Robertson SMITHFIELD, Virginia (Reuters) - Painted pig statues grace the picturesque brick sidewalks of this small Virginia river town of 8,000, and its slogan, "Hams, History and Hospitality," probably tells visitors all they need to know about Smithfield and its relationship with Smithfield Foods, the world's largest hog producer. Earlier this week, Smithfield Foods received a $4.7 billion buyout offer from a Chinese food company. News that an agreement had been reached and was awaiting U.S. ...

Source: http://news.yahoo.com/dutch-authorities-cull-poultry-avian-influenza-outbreak-122024003.html

netflix george h w bush Belk Led Zeppelin

Syria: Car bomb kills 3 in Damascus suburb

This citizen journalism image provided by the Local Council of Barzeh, which has been authenticated based on its contents and other AP reporting, shows destroyed homes from government airstrikes and shelling, in the Barzeh district of Damascus, Syria, Saturday, June 1, 2013. More than a dozen rockets and mortar rounds fired from Syria struck eastern Lebanon on Saturday, security officials said, as tensions escalated along the Lebanese-Syria border over the increasing role of Hezbollah militants in the civil war next door. (AP Photo/Local Council of Barzeh)

This citizen journalism image provided by the Local Council of Barzeh, which has been authenticated based on its contents and other AP reporting, shows destroyed homes from government airstrikes and shelling, in the Barzeh district of Damascus, Syria, Saturday, June 1, 2013. More than a dozen rockets and mortar rounds fired from Syria struck eastern Lebanon on Saturday, security officials said, as tensions escalated along the Lebanese-Syria border over the increasing role of Hezbollah militants in the civil war next door. (AP Photo/Local Council of Barzeh)

(AP) ? A Syrian government official says a car bomb has exploded in a suburb of the capital Damascus, killing three people and wounding several others.

The Britain-based Syrian Observatory for Human Rights confirmed the Sunday explosion in Jouber, which it said has seen heavy clashes recently between rebels and the Syrian army. It did not have any immediate word on casualties.

It said the blast targeted a police station and was carried out by the Jabhat al-Nusra, a militant group linked to al-Qaida, but did not elaborate.

The government official insisted on anonymity because he is not allowed to make press statements.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-06-02-ML-Syria/id-71cd1268dc1145bf877774b3cecb04a4

seahawks new uniforms 2012 tornadoes in dallas anchorman 2 kentucky basketball

Kendrick Lamar Gives A good kid's Perspective On 'Menace II Society'

Two decades after its release, Kendrick talks to 'RapFix Live' about the gritty coming-of-age flick.
By Rob Markman, with reporting by Sway Calloway


Kendrick Lamar
Photo: Tim Mosenfelder/ Getty Images

Source: http://www.mtv.com/news/articles/1708274/kendrick-lamar-menace-ii-society-anniversary.jhtml

prometheus trailer patrice oneal shamrock slainte

Tetris creator launches Marbly, his first mobile-focused game

Tetris creator builds Marbly, his first mobilefirst game

Alexey Pajitnov certainly has a presence on phones and tablets when there's a seemingly infinite number of Tetris ports. His newly released Marbly is his first game built with mobile in mind, however. The iOS puzzler isn't as action-packed as Tetris or even Hexic, but it's as deceptively simple as Pajitnov's earlier work: players have to think several steps ahead as they match like-colored marbles. The game is easy enough to try when it's free, with in-app purchases available when gamers need a helping hand. It's also just the beginning of Pajitnov's mobile efforts -- publisher WildSnake Software claims that he's working on more releases, which suggests that there's plenty of all-too-addictive gameplay in our future.

Filed under: , ,

Comments

Via: Pocket-lint

Source: App Store

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/LPP8a9AwG1k/

toys r us kohls target target

Coming soon? Nutritional labels on alcohol drinks

WASHINGTON (AP) ? Alcohol beverages soon could have nutritional labels like those on food packaging, but only if the producers want to put them there.

The Treasury Department, which regulates alcohol, said this past week that beer, wine and spirits companies can use labels that include serving size, servings per container, calories, carbohydrates, protein and fat per serving. Such package labels have never before been approved.

The labels are voluntary, so it will be up to beverage companies to decide whether to use them on their products.

The decision is a temporary, first step while the Alcohol and Tobacco Trade and Tax Bureau, or TTB, continues to consider final rules on alcohol labels. Rules proposed in 2007 would have made labels mandatory, but the agency never made the rules final.

The labeling regulation, issued May 28, comes after a decade of lobbying by hard liquor companies and consumer groups, with clearly different goals.

The liquor companies want to advertise low calories and low carbohydrates in their products. Consumer groups want alcoholic drinks to have the same transparency as packaged foods, which are required to be labeled.

"This is actually bringing alcoholic beverages into the modern era," says Guy Smith, an executive vice president at Diageo, the world's largest distiller and maker of such well-known brands as Johnnie Walker, Smirnoff, Jose Cuervo and Tanqueray.

Diageo asked the bureau in 2003 to allow the company to add that information to its products as low-carbohydrate diets were gaining in popularity.

Almost 10 years later, Smith said he expects Diageo gradually to put the new labels on all of its products, which include a small number of beer and wine companies.

"It's something consumers have come to expect," Smith said. "In time, it's going to be, why isn't it there?"

Not all alcohol companies are expected to use labels. Among those that may take a pass are beer companies, which don't want consumers counting calories, and winemakers, which don't want to ruin the sleek look of their bottles.

The Wine Institute, which represents more than a thousand California wineries, said in a statement that it supports the ruling but "experience suggests that such information is not a key factor in consumer purchase decisions about wine."

Spokeswoman Gladys Horiuchi said the group knows of no wine companies that plan to use the new labels.

The beer industry praised the agency for acknowledging that labels should take into account variations in the concentration of alcohol content in different products.

The industry has opposed the idea of defining serving size by fluid ounces of pure alcohol ? or as 12 ounces of beer, 5 ounces of wine or 1.5 ounces of 80-proof liquor ? on the grounds that you may get more than 1.5 ounces of liquor in a cocktail depending on what else is in the drink and the accuracy of the bartender.

The ruling would allow the labels to declare alcohol content as a percentage of alcohol by volume, the approach favored by the beer industry.

"We applaud the TTB's conclusion that rules be based on how drinks are actually served and consumed," said Joe McClain, president of the Beer Institute.

McClain said the beer industry is pleased that the ruling provides "substantial flexibility" in terms of the format and placement of the disclosure on packaging.

It is unclear whether beer companies will actually use the labels, however.

Consumer advocates criticized the regulation.

"It doesn't reflect any concern about public health," said Michael Jacobson, director of the Center for Science in the Public Interest. He said the rules are too close to what the alcohol companies had sought.

Consumer advocates have said that listing alcohol content should be mandatory so consumers know how much they are drinking. Jacobson and others also support having calorie counts on labels, but they said the labels should not include nutrients that make the alcohol seem more like a food.

"Including fat and carbohydrates on a label could imply that an alcoholic beverage is positively healthful, especially when the drink's alcohol content isn't prominently labeled," Jacobson said.

Current labeling law is complicated.

Wines containing 14 percent or more alcohol by volume must list alcohol content. Wines that are 7 percent to 14 percent alcohol by volume may list alcohol content or put "light" or "table" wine on the label. "Light" beers must list calorie and carbohydrate content only. Liquor must list alcohol content by volume and may also list proof, a measure of alcoholic strength.

Wine, beer and liquor manufacturers don't have to list ingredients but must list substances people might be sensitive to, such as sulfites, certain food colorings and aspartame.

Tom Hogue of the TTB said the aim of the ruling is to make sure alcohol labeling is more consistent. "The idea here is we are trying to make it easy for the industry to communicate this with consumers if they want to do so, and if their consumers want them to do it," he said.

___

Follow Mary Clare Jalonick on Twitter at http://twitter.com/mcjalonick

___

Online:

Labeling guidance: http://www.ttb.gov/rulings/2013-2.pdf

Source: http://news.yahoo.com/coming-soon-nutritional-labels-alcohol-drinks-140825454.html

walmart best buy sears Aeropostale

Lucroy, Peralta help Brewers top Phillies 4-3

PHILADELPHIA (AP) ? Francisco Rodriguez and the Milwaukee Brewers had a little extra help holding off the Phillies.

Second-base umpire Mike Estabrook called pinch-runner Kyle Kendrick out on a pickoff even though shortstop Jean Segura tagged him without the ball and the Brewers held on to beat Philadelphia 4-3 on Saturday.

Kendrick was the second out of the inning, and the next batter doubled before Rodriguez was able to nail down his third straight save.

After the game, crew chief Tom Hallion told a pool reporter that it was an incorrect call after looking at replay.

"The ball goes in the glove and comes out of the glove with Kendrick diving back in and with Segura diving back for the ball," Hallion told a pool reporter. "Obviously, Mike was in the right position to make a pickoff play call like that. But the way that the play developed, the ball comes free and rolls right in Segura's bare hand and he comes up shows him the ball."

Before the ninth, Jonathan Lucroy homered and Wily Peralta tossed seven strong innings for Milwaukee.

After Rodriguez intentionally walked Domonic Brown, he retired Michael Martinez on a groundout to end the game. Kendrick went right to the video room after the play and said he was "just mad" when he saw the replay.

"He was in a bad position to see that, but that was the game," Kendrick said. "I score right there and we have a tie game and anything can happen."

Logan Schafer went 3-for-4 with a pair of doubles and an RBI for Milwaukee, which won its second straight after finishing May tied for the worst winning percentage (.214) in club history.

"We got some breaks again today," Milwaukee manager Ron Roenicke said. "This game is fun because you're always trying to figure it out. It's frustrating because you can't do anything about it. It really isn't fair."

Peralta (4-6) entered on a four-game losing streak but had one of his best outings of the season, surrendering two runs and eight hits with six strikeouts and a walk. Peralta successfully pitched out of trouble throughout and stranded runners at second in four of his seven innings, including when he struck out Brown with his final pitch in the seventh.

Brown had 12 homers in May with six in his last five games. He went 1-for-4 with a single and a pair of strikeouts Saturday. Freddy Galvis homered and Hernandez went 3-for-5 with a double for Philadelphia, which lost its third straight and fifth in seven games. The Phillies dropped to 8-24 when scoring three runs or less.

Galvis homered to lead off the ninth before Jimmy Rollins, who didn't start due to a sore foot, followed with a pinch-hit single. Kendrick ran for Rollins and went to second on Ben Revere's sacrifice bunt, but was picked off.

"It's unfortunate, but it's one of those plays that if any one of us ? any umpire ? had seen the loose ball, we certainly would have come in and helped Mike out with that," Hallion said. "The problem was that I don't think anybody saw the ball. I don't think anyone from the Phillies dugout or the Brewers dugout or Kendrick knew that the ball was on the ground."

After the Kendrick out, Rodriguez intentionally walked Brown to put runners on first and second with two outs before getting Michael Martinez to ground out to end the game.

"It's kind of how things have been going for us," Phillies manager Charlie Manuel said.

Tyler Cloyd (1-2) gave up three runs (two earned) on eight hits with three strikeouts and one walk in seven innings.

Delmon Young was responsible for two of the Brewers' first three runs, as his throwing error in the second inning allowed Lucroy to score after Schafer's RBI single that also scored Aramis Ramirez and gave Milwaukee a 2-0 lead.

Kevin Frandsen's RBI groundout in the fourth pulled the Phillies within 2-1. But the Brewers got the run back in the fifth when Segura tripled for a 3-1 lead.

Philadelphia closed within 3-2 on Erik Kratz's RBI single in the sixth, but Lucroy homered to left with two outs in the eighth off reliever Mike Adams. It was the third homer in two games for Lucroy, who went 5-for-5 with two homers and a double in Friday's 8-5 win over Philadelphia.

Notes: Schafer was filling in for regular center fielder Carlos Gomez, who got the day off. . Brown became the first player in Major League history with at least 10 homers and no walks in a month. . Brewers right-hander Mike Fiers (1-3, 5.66) is scheduled to face Phillies lefty Cliff Lee (6-2, 2.34) in the finale of the three-game series at 1:35 Sunday.

Source: http://news.yahoo.com/lucroy-peralta-help-brewers-top-phillies-4-3-005141737.html

cbs sports ncaa tournament kids choice awards Miley Cyrus Twerk

Saturday, June 1, 2013

How 'Philadelphia' Joe Took Control of Diabetes with Health and ...


Diagnosed with Type II Diabetes 5 years ago, Joe struggled to control his weight and live a healthy lifestyle. He finally got serious in January of 2012 and found hope with his personal trainer, Matt. Discover what Joe has learned and how he controlled his diabetes in this NEW episode of ?PASS the BALL!?

Like this:

Like Loading...

Source: http://blog.lafitness.com/2013/05/31/how-philadelphia-joe-took-control-of-diabetes-with-health-and-fitness/

lent la times heart attack grill KTLA

Bowling Green Athletics - Falcons Fall In First NCAA Tournament ...

Box Score | Photo Gallery | Postgame Press Conferences (Danny Schmitz, Mike Frank, Jeremy Shay)

LOUISVILLE, Ky.?Playing in their first NCAA Tournament game in 14 years, the Bowling Green State University baseball team was defeated by University of Louisville, 8-3, on Friday night in the NCAA Louisville Regional. The game, which was played at UofL?s Jim Patterson Stadium, was the first NCAA Tournament contest for the program since 1999.
?
Despite an early lead in the game, the Falcons committed two errors and allowed the Cardinals to grab momentum. With the loss, Bowling Green drops to 24-30 on the season. The Falcons are 2-7 all-time in the NCAA Tournament.
?
After the first two were out in the top of the first, junior Jeremy Shay would give the Falcons a lead with his sixth home run of the season. Shay would get a two-strike slider from UofL starter Chad Green, depositing it into the crowd over the left-center field wall.
?
Falcons? starting pitcher Mike Frank got off to a good start, retiring the Cardinals in order in the first. But, Louisville would tie the game in the bottom of the second, as Coco Johnson got on top of a 1-0 fastball for a solo home run.
?
Following a 25-minute rain delay in the bottom of the third, Louisville would have a runner on first with nobody out. A sacrifice bunt would advance the runner to second with one out, but T.J. Losby would catch the runner attempting to steal third for the second out of the inning. Frank would get a ground ball which looked like it would get him out of the inning, but an errant throw to first would allow a UofL runner to reach base. After a wild pitch advanced the runner to second, Johnson would mash his second home run of the game to give the Cardinals a 3-1 lead.
?
Four Louisville hits coupled with a Falcon error opened the door for a big UofL inning, as they would score four times in the fifth to open up a commanding 7-1 lead.
?
The Falcons would get two runs back in the top of the sixth inning, closing the gap to 7-3. Brian Bien, who was on base three times in the game, began the frame with a walk. Patrick Lancaster would then double into the left field bullpen, with Bien coming all the way around from first to score. Following a line out, Shay would single to put runners on the corners with one out. Losby would elevate a ball during the next at-bat into left-center field, the flyout carrying deep enough to bring Lancaster home from third.
?
Louisville would add a run in the bottom of the sixth, as the Cardinals turned a leadoff single into an 8-3 lead.
?
That would be the only run that reliever Ethan McKenney would surrender, as he went the final three innings.
?
The Falcons could not scratch a hit across the board in the final three innings, as three UofL relievers combined to hold the Falcons at bay down the stretch.
?
The Falcons, with their backs against the wall, will fight for their lives tomorrow afternoon. The Falcons will play Oklahoma State in an elimination game beginning at 12:00 p.m. Cody Apthorpe will start the game for the Orange and Brown. Last season, OSU swept a series from the Falcons in Stillwater.
?
Notes
*Mike Frank went 5.0 innings on Friday, moving into 2nd all-time in a single season with 102.1 innings pitched. Frank also moved into 8th all-time with 224.2 career innings pitched.
?
*Frank struck out three on Friday, moving his single season total to 80. Frank moved into a tie for 7th in a single season.
?
*Jeremy Shay?s home run moved him into a tie for the team lead, with six. Shay also is tied for the team lead with 38 RBI.
?
*Ethan McKenney now has a season ERA of 1.99, giving up just 11 earned runs in 49.2 innings pitched. If McKenney?s mark holds, it would give him the 12th lowest ERA all-time for a single season in program history.

Source: http://www.bgsufalcons.com/news/2013/5/31/BB_0531135358.aspx

sandy Time Change 2012 news 12 world series

Despite Criticism, FWD.us Adds YouTube Co-Founder Steve Chen And Web Mogul Barry Diller As Funders

FWD Chen DillerAmidst widespread criticism, Mark Zuckerberg's political advocacy group FWD.us gained some momentum today as it announced Steven Chen and Barry Diller have signed on as financial backers. Chen was a co-founder of YouTube, and Diller is the chairman of IAC/InterActiveCorp which owns About, Match, Newsweek and Vimeo. Diller and Chen, an immigrant himself, will fund campaigns for immigration reform.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/XISFREux4lM/

survivor tiger woods titus young Kristen Wiig

Will Smith Seduced M. Night Shyamalan With 'After Earth' Pitch

Director explains how signing onto 'After Earth' was like saying 'yes' to a date with your crush.
By Todd Gilchrist

Source: http://www.mtv.com/news/articles/1708267/after-earth-will-smith-m-night-shyamalan.jhtml

state of the union fat tuesday ash wednesday kate middleton

Snoop Lion, Miley Cyrus Reflect On Life's Changes In 'Ashtrays' Video

The duo take an outsider's look at transformation in new clip.
By Rob Markman

Source: http://www.mtv.com/news/articles/1708290/snoop-lion-miley-cyrus-ashtrays-heartbreaks-music-video.jhtml

glee glee masters live frozen four

90% Beyond The Hills

All Critics (80) | Top Critics (30) | Fresh (72) | Rotten (8)

The final shot, with windshield wipers struggling to clean away a torrent of muddy water, suggests that no human agency is great enough to handle this world's misery.

"Beyond the Hills" seethes with astonishment and rage at a broken society marooned between the 21st century and the 16th.

It is a haunting movie, dealing with superstitions, possession, even exorcism, one in which Mungiu poses no easy answers, because there are none to be found.

If you long for the bleak intelligence of an Ingmar Bergman film, where humankind is deeply flawed and God is indifferently silent and the landscape is cloaked in perpetual winter, then Beyond the Hills promises to be your cup of despair.

There are no easy villains or heroes in this sad and slow but forcefully told tale, which exhibits the same humanity Mungiu brought to 4 Months, 3 Weeks and 2 Days, his abortion drama that won the 2007 Palme d'Or.

A film that asks its viewer to consider the nature of good and evil, love and trust - and trust that turns into something like blind faith.

You'd swear Mungiu has inherited the spirit of Ingmar Bergman. All that's missing is the stark black-and-white photography.

Beyond the Hills' undercurrents prove more interesting than its storyline or characters.

Strikingly shot and punishingly long ...

(Writer-director Christian) Mungiu balances his film's more disturbing content with peaceful shots of the idyllic, surrounding countryside and of intimacy between the two women while slowly building to an inevitable conclusion.

When the ill and unstable Alina returns to the monastery, just so she can be with her beloved, Beyond the Hills becomes a species of those exorcism movies that audiences gorge on, only done with a realism and ambiguity usually missing from the genre.

What makes this movie unique is that it holds literally everyone in the film accountable for the unfortunate goings on.

It's an exorcism movie for everyone who thought, after Mungiu's gruelling abortion buddy-movie 4 Months, 3 Weeks and 2 Days, that this guy should do an exorcism movie

It's an enigmatic and austere film from a region where political, sexual and religious repression are as stifling as the sooty air.

Mungui's rigorous approach to filmmaking isn't a ton of fun to watch, but his ideas stick with you.

It delivers an emotional punch, in what its director has called a story about the sin of indifference.

Such is the rigorous and high-minded nature of Romanian cinema that even a real-life exorcism story can inspire something loftier than a horror movie.

Heartbreak at a Romanian convent

...Cristian Mungiu has taken a real life event...to consider deeply human philosophies such as freedom vs. discipline, love vs. security, the choices facing those without financial recourse and the hypocrisies of organized religions.

I found it riveting to watch and fascinating to think about afterwards.

No quotes approved yet for Beyond The Hills. Logged in users can submit quotes.

Source: http://www.rottentomatoes.com/m/beyond_the_hills_2012/

orrin hatch marlon byrd charles colson humber

Xi, Obama look to strike up relationship at summit

BEIJING (AP) ? President Barack Obama and Chinese President Xi Jinping face weighty issues when they meet at a private estate in California next week, but their most important task may simply be establishing a strong rapport.

Tucked away at a mansion with a private golf course on the edge of the Mojave Desert, Obama and Xi will search for the kind of personal chemistry that has eluded their predecessors for the past several decades. With the bilateral relationship growing ever more critical and complex, how well the leaders click matters even more now.

Distrust has grown between the world's sole superpower and the rising Asian giant. Beijing sees Washington as trying to thwart China's ascendancy. The U.S. accuses China of widespread computer hacking and unfair trade. Meanwhile, there's worry their militaries might be drawn into conflict as China tries to elbow aside U.S. allies Japan and the Philippines over disputed, remote islands.

"There are a lot of problems between China and the U.S. that aren't going to be easy to solve. The hope, therefore, is that a way can be established so that at the times of crisis, dialogue will prevail based on trust and the personal relationship between the two leaders," said Zhu Feng, deputy director of the Center for International and Strategic Studies at Peking University.

The June 7-8 get-together at the private Sunnylands estate of late publishing tycoon Walter Annenberg is the first face-to-face meeting between the presidents since Obama's re-election and Xi's promotion to Communist Party chief last November. Under China's dual party-government system, Xi didn't officially assume the title of president until March.

The summit comes months before the two leaders had been originally scheduled to meet, highlighting a perception on both sides that the leaders need to refocus on the U.S.-China relationship following their political transitions and amid myriad distractions at home and abroad.

The accelerated timing constitutes "a clear message that China wants to emphasize the importance of U.S.-China relations for the future," said Cheng Li, a Chinese politics expert at the Brookings Institution in Washington, D.C.

It's not clear yet how big the two delegations will be or whether Xi and Obama will meet one-on-one. Li said that's something Xi's stiff and formal predecessor, Hu Jintao, was unwilling to do.

But there are hopeful signs that the two men will gel. Xi already has a warm relationship with Vice President Joe Biden, whom he accompanied to western China on a visit in 2011. Xi also boasts a greater familiarity with the U.S. than any of his predecessors, having visited frequently and maintained his ties to families he stayed with in Muscatine, Iowa, while a visiting provincial official in 1985. He also sent his daughter to Harvard.

The two men share a love of sports: swimming and football on Xi's side, basketball and golf on Obama's. Both are married to glamorous, high-profile wives who have played a strong role in shaping their images.

Xi's wife, People's Liberation Army songstress Peng Liyuan, was for many years better known to the public than her husband. Chinese media and Internet users closely followed her activities during the couple's first formal state visits to Russia and three African countries earlier this year.

"It will be interesting to see how the chemistry will develop. It's important, because particularly in China, personal relationships always carry a lot of weight in state-to-state relations," said the Brookings Institution's Li.

Xi has already proved himself a different leader by his pragmatism. With relations edgy, he was willing to forgo the pomp of an official White House visit for the lower-key meeting in California.

Trust between the countries has dwindled over the decades. After U.S. planes bombed the Chinese Embassy in Yugoslavia in what Washington says was an accident during the Kosovo war in 1999, angry Chinese protesters nearly breached the U.S. Embassy in Beijing. In the discord, Chinese President Jiang Zemin refused a call from the White House. Two years later, when a Chinese fighter jet collided with a U.S. surveillance plane off southern China, Beijing held the American crew and waited for an acceptable apology from the U.S.

In 2009, the U.S. Navy accused Chinese sailors of harassing one of its ocean floor mapping vessels in a game of high-seas chicken.

The trust gap was further underscored by newly publicized claims Tuesday that China employed cyberattacks to access data from nearly 40 Pentagon weapons programs and almost 30 other defense technologies ranging from missile defense systems to the F-35 joint strike fighter.

The disclosure was included in a Defense Science Board report released earlier this year, meaning U.S. officials knew of it before planning for the summit began. The disclosure's public release allows U.S. officials to highlight an issue of concern without necessarily overshadowing the summit.

China's Defense Ministry on Thursday called the accusations faulty and said they underestimated both the Pentagon's ability to protect its secrets, and the capabilities of China's domestic defense industry.

"China is entirely capable of producing the weaponry needed for national defense," spokesman Geng Yansheng told reporters at a monthly briefing, pointing to recent domestic technological breakthroughs such as the country's first aircraft carrier, new generation fighter jets, large transport planes and the Beidou satellite system.

China has consistently denied claims its military is engaged in hacking, including those in a report by U.S. cybersecurity firm Mandiant that traced the hacking back to a People's Liberation Army unit based in Shanghai.

Other likely agenda items include the North Korean and Iranian nuclear programs, conflict in Syria, climate change and expanding bilateral military ties. China will likely press its claims of business discrimination in the U.S. market, along with its deep discomfort over Washington's shifting of military assets to Asia and renewed emphasis on its regional alliances, moves seen by China as part of an effort to contain its rise.

The perception of U.S. decline and Chinese ascendancy forms much of the subtext to the current relationship, with Beijing seeking greater international influence commensurate with its status as the world's second-largest economy. Many in China see the U.S. as a waning power weakened by the economic crisis, partisan feuding and the conflicts in Iraq and Afghanistan.

In their latest contribution to diplomatic argot, Chinese leaders now say they are seeking a "new model of major country relations" in their dealings with Washington. Assistant Foreign Minister Zheng Zeguang defined that Wednesday as "different from the old model featuring confrontation and conflict."

"We believe a new model of major country relations between China and the United States should be based on mutual trust, equality, inclusiveness, mutual learning and win-win cooperation," Zheng said at a Wednesday briefing.

Xi and Obama first met early last year when Xi, then China's vice president, visited the White House on a trip to meet key American political players and introduce himself to the American public. The visit afforded Xi a chance to show his human side, reconnecting with his old Iowa friends, chatting with students at a school in Los Angeles and even catching part of a Lakers basketball game.

Known primarily for his pedigree as the son of a communist elder, Xi is seen by many observers as a strong nationalist willing to press territorial claims and what Beijing broadly proclaims as the "great rejuvenation of the Chinese nation."

Unlike former President Hu, who often seemed uncomfortable outside official settings and stuck closely to his official talking points, Xi appears at ease around foreign visitors and is known for speaking without notes and allowing sessions to run well over their scheduled time limits.

"On a personal level, he's confident, he's on top of his brief and you get a very distinct sense that he has a roadmap in his head in terms of where China needs to go. He's not only a very adroit political operator, but he's also a realist," said former U.S. Ambassador to China Jon Huntsman.

___

Pennington reported from Washington.

Source: http://news.yahoo.com/xi-obama-look-strike-relationship-summit-084428710.html

pi day Samsung Galaxy S4 St Francis Anquan Boldin

Researchers gain insight into key protein linked to cancers, neurodegenerative disorders

May 30, 2013 ? Virginia Commonwealth University researchers studying a key molecular player called Hsp70 that is responsible for protein homeostasis have uncovered how it binds together with another molecule responsible for intracellular energy transfer to enhance its overall activity and efficiency -- details that have previously not been well understood.

Heat shock proteins, particularly the 70-kilodalton heat shock proteins, Hsp70, are important for cellular processes such as protein folding and protecting cells from stress. It is also involved with protein assembly, degradation and transport. Imbalances in protein homeostasis have been previously found to contribute to the onset of neurodegenerative diseases and cancers.

In the study, published this week in the Online First section of Nature Structural & Molecular Biology, a publication of the Nature journal family, researchers conducted a biochemical analysis of the structure to learn how ATP binding allosterically opens the polypeptide-binding site. In order for Hsp70 to do its job of regulating its binding to unfolded polypeptide substrates, it gains energy from the process of ATP hydrolysis. ATP is a molecule responsible for intracellular energy transfer.

The team found that when Hsp70 binds ATP it promotes the allosteric opening of the polypeptide binding site.

"Due to their essential roles in protein trafficking and proper folding since mis-folded proteins can disrupt cell function, Hsp70s are inextricably linked to the development of cancers, aging and neurodegenerative disorders," said Qinglian Liu, Ph.D., assistant professor in the Department of Physiology and Biophysics in the VCU School of Medicine.

"Understanding the structural properties at the atomic level and molecular working of Hsp70s will pave the foundation for designing efficient and potent small molecule drugs to specifically modulate the function of Hsp70s. The small molecule drugs may become novel and efficient treatments for cancers or neurodegenerative disorders," she said.

Liu said that the team's structural and biochemical analysis revealed how Hsp70s use ATP to open their peptide substrate binding site and thus regulate their ability in binding peptide substrates.

"These findings help us understand at the atomic level how Hsp70s function in maintaining the well-being of cellular proteins, such as folding, assembly, transport and degradation," said Liu.

According to Liu, future work will move the team in two directions. First, based on this published work, they aim to design specific and potent modulators for Hsp70s and test their potential in treating cancers or neurodegenerative disorders. A second focus will be to study how Hsp70s cooperate with their Hsp40 partners to achieve their optimum activity in maintaining protein homeostasis.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/Kc_sJWF6cQQ/130530153342.htm

yield crossbow airhead atherosclerosis

The White House hosting a 'We the Geeks' Hangout later today, plans to talk asteroids

The White House is hosting a 'We the Geeks' Hangout this afternoon, plans to talk asteroids

Ever since joining Google+ early last year, The White House has become more and more involved with the social network. And with word spreading amongst Earthlings about the potential sighting of an asteroid (with its own moon, no less) sometime around 5:00PM ET, the executive mansion of the US couldn't have chosen a better day to discuss the topic. As part of its ongoing "We the Geeks" series on Google+, The White House will be hosting a Hangout today where it plans to talk about asteroid characterization, identification, resource utilization and more. As you'd expect, there will be a some knowledgeable people present to spark the conversation, including NASA Deputy Administrator Lori Garver, former astronaut Ed Lu and, of course, Bill Nye. So, if you plan to fly swing by later, be sure to set a reminder for 2:00PM ET, as that's when the Hangout is expected to begin.

Filed under: ,

Comments

Source: The White House

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/JA-AlshoXu0/

luke scott tom benson royals nicole richie